Selective Mediator-dependence of cell type-specifying transcription

The Mediator complex directs signals from DNA-binding transcription factors to RNA polymerase (Pol) II. Despite this pivotal position, mechanistic understanding of Mediator in human cells remains incomplete. Here, we quantified Mediator-controlled Pol II kinetics by coupling rapid subunit degradatio...

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Publicado en:Nat Genet
Autores principales: Jaeger, Martin G., Schwalb, Björn, Mackowiak, Sebastian D., Velychko, Taras, Hanzl, Alexander, Imrichova, Hana, Brand, Matthias, Agerer, Benedikt, Chorn, Someth, Nabet, Behnam, Ferguson, Fleur M., Müller, André C., Bergthaler, Andreas, Gray, Nathanael S., Bradner, James E., Bock, Christoph, Hnisz, Denes, Cramer, Patrick, Winter, Georg E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610447/
https://ncbi.nlm.nih.gov/pubmed/32483291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0635-0
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