CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation

Cyclin-dependent kinase 12 (CDK12) phosphorylates the carboxyl-terminal domain (CTD) of RNA polymerase II (pol II) but its roles in transcription beyond the expression of DNA damage response genes remain unclear. Here, we have used TT-seq and mNET-seq to monitor the direct effects of rapid CDK12 inh...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Tellier, Michael, Zaborowska, Justyna, Caizzi, Livia, Mohammad, Eusra, Velychko, Taras, Schwalb, Björn, Ferrer-Vicens, Ivan, Blears, Daniel, Nojima, Takayuki, Cramer, Patrick, Murphy, Shona
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641311/
https://ncbi.nlm.nih.gov/pubmed/32805052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa514
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