Herpes Simplex Virus 1 (HSV-1) ICP22 Protein Directly Interacts with Cyclin-Dependent Kinase (CDK)9 to Inhibit RNA Polymerase II Transcription Elongation

The Herpes Simplex Virus 1 (HSV-1)-encoded ICP22 protein plays an important role in viral infection and affects expression of host cell genes. ICP22 is known to reduce the global level of serine (Ser)2 phosphorylation of the Tyr1Ser2Pro3Thr4Ser5Pro6Ser7 heptapeptide repeats comprising the carboxy-te...

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Detalhes bibliográficos
Main Authors: Zaborowska, Justyna, Baumli, Sonja, Laitem, Clelia, O'Reilly, Dawn, Thomas, Peter H., O'Hare, Peter, Murphy, Shona
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169428/
https://ncbi.nlm.nih.gov/pubmed/25233083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107654
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