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Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

Controlled perturbation of protein activity is essential to study protein function in cells and living organisms. Small molecules that hijack the cellular protein ubiquitination machinery to selectively degrade proteins of interest, so-called degraders, have recently emerged as alternatives to selec...

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Dettagli Bibliografici
Pubblicato in:Nat Struct Mol Biol
Autori principali: Wu, Tao, Yoon, Hojong, Xiong, Yuan, Dixon-Clarke, Sarah, Nowak, Radosław P., Fischer, Eric S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923177/
https://ncbi.nlm.nih.gov/pubmed/32541897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0438-0
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