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Targeted protein degradation as a powerful research tool in basic biology and drug target discovery
Controlled perturbation of protein activity is essential to study protein function in cells and living organisms. Small molecules that hijack the cellular protein ubiquitination machinery to selectively degrade proteins of interest, so-called degraders, have recently emerged as alternatives to selec...
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| Veröffentlicht in: | Nat Struct Mol Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7923177/ https://ncbi.nlm.nih.gov/pubmed/32541897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0438-0 |
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