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Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

Controlled perturbation of protein activity is essential to study protein function in cells and living organisms. Small molecules that hijack the cellular protein ubiquitination machinery to selectively degrade proteins of interest, so-called degraders, have recently emerged as alternatives to selec...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Wu, Tao, Yoon, Hojong, Xiong, Yuan, Dixon-Clarke, Sarah, Nowak, Radosław P., Fischer, Eric S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923177/
https://ncbi.nlm.nih.gov/pubmed/32541897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0438-0
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