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Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

Controlled perturbation of protein activity is essential to study protein function in cells and living organisms. Small molecules that hijack the cellular protein ubiquitination machinery to selectively degrade proteins of interest, so-called degraders, have recently emerged as alternatives to selec...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Wu, Tao, Yoon, Hojong, Xiong, Yuan, Dixon-Clarke, Sarah, Nowak, Radosław P., Fischer, Eric S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923177/
https://ncbi.nlm.nih.gov/pubmed/32541897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0438-0
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