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Proteolysis Targeting Chimeras as Therapeutics and Tools for Biological Discovery
New biological tools provide new techniques to probe fundamental biological processes. Here we describe the burgeoning field of Proteolysis Targeting Chimera (PROTACs) which are capable of modulating protein concentrations at a post-translational level by co-opting the Ubiquitin-Proteasome System. W...
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| Publicado en: | Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7319047/ https://ncbi.nlm.nih.gov/pubmed/31955850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.11.031 |
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