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Proteolysis Targeting Chimeras as Therapeutics and Tools for Biological Discovery

New biological tools provide new techniques to probe fundamental biological processes. Here we describe the burgeoning field of Proteolysis Targeting Chimera (PROTACs) which are capable of modulating protein concentrations at a post-translational level by co-opting the Ubiquitin-Proteasome System. W...

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Bibliografski detalji
Izdano u:Cell
Glavni autori: Burslem, George M., Crews, Craig M.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319047/
https://ncbi.nlm.nih.gov/pubmed/31955850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.11.031
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