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Design, Synthesis and Biological Evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK Degraders with Improved Pharmacokinetic Properties
A new series of Proteolysis Targeting Chimeras (PROTACs) targeting Bruton’s Tyrosine Kinase (BTK) was synthesized, with the goal of improving the pharmacokinetic properties of our previously reported PROTAC, MT802. We recently described the ability of MT802 to induce degradation of both wild-type an...
Shranjeno v:
| izdano v: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7318425/ https://ncbi.nlm.nih.gov/pubmed/31879210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126877 |
| Oznake: |
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