Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Proteolysis Targeting Chimera (PROTAC) technology is a rapidly emerging alternative therapeutic strategy with the potential to address many of the challenges currently faced in modern drug development programs. PROTAC technology employs small molecules that recruit target proteins for ubiquitination...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Lai, Ashton C., Toure, Momar, Hellerschmied, Doris, Salami, Jemilat, Jaime-Figueroa, Saul, Ko, Eunhwa, Hines, John, Crews, Craig M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733637/
https://ncbi.nlm.nih.gov/pubmed/26593377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201507634
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