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Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

With the discovery of PROteolysis TArgeting Chimeras (PROTACs) twenty years ago, targeted protein degradation (TPD) has changed the landscape of drug development. PROTACs have evolved from cell-impermeable peptide-small molecule chimeras to orally bioavailable clinical candidate drugs that degrade o...

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Detalhes bibliográficos
Publicado no:RSC Chem Biol
Main Authors: Bond, Michael J., Crews, Craig M.
Formato: Artigo
Idioma:Inglês
Publicado em: RSC 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190915/
https://ncbi.nlm.nih.gov/pubmed/34212149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1cb00011j
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