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Proteolysis-targeting chimeras (PROTACs) in cancer therapy
Abstract Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits target protein and E3 ubiquitin ligase together to trigger proteasomal degradation of target protein by the ubiquit...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2022-04-01
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| Colecção: | Molecular Cancer |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s12943-021-01434-3 |
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