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PROteolysis TArgeting Chimeras (PROTACs) - Past, Present and Future
The majority of currently used therapeutics are small molecule-based and utilize occupancy-driven pharmacology as the mode of action (MOA), in which the protein function is modulated via temporary inhibition. New modalities that operate using alternative MOAs are essential for tapping into the “undr...
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| Publicado no: | Drug Discov Today Technol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6578591/ https://ncbi.nlm.nih.gov/pubmed/31200855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2019.01.002 |
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