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PROteolysis TArgeting Chimeras (PROTACs) - Past, Present and Future
The majority of currently used therapeutics are small molecule-based and utilize occupancy-driven pharmacology as the mode of action (MOA), in which the protein function is modulated via temporary inhibition. New modalities that operate using alternative MOAs are essential for tapping into the “undr...
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| 出版年: | Drug Discov Today Technol |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6578591/ https://ncbi.nlm.nih.gov/pubmed/31200855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2019.01.002 |
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