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Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and o...
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| 發表在: | Cell Chem Biol |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5610075/ https://ncbi.nlm.nih.gov/pubmed/28648379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.05.024 |
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