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Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and o...

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Bibliografiske detaljer
Udgivet i:Cell Chem Biol
Main Authors: Cromm, Philipp M., Crews, Craig M.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610075/
https://ncbi.nlm.nih.gov/pubmed/28648379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.05.024
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