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Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and o...

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書目詳細資料
發表在:Cell Chem Biol
Main Authors: Cromm, Philipp M., Crews, Craig M.
格式: Artigo
語言:Inglês
出版: 2017
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610075/
https://ncbi.nlm.nih.gov/pubmed/28648379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.05.024
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