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Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Traditional pharmaceutical drug discovery is almost exclusively focused on directly controlling protein activity to cure diseases. Modulators of protein activity, especially inhibitors, are developed and applied at high concentration to achieve maximal effects. Thereby, reduced bioavailability and o...
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| Veröffentlicht in: | Cell Chem Biol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5610075/ https://ncbi.nlm.nih.gov/pubmed/28648379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.05.024 |
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