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Chemical Inducers of Targeted Protein Degradation

The functions of many cellular proteins have been elucidated by selective gene inactivation and subsequent phenotypic analysis. For example, genetic mutations, gene knock-out generation, and the use of RNA interference to target mRNA for degradation can all result in decreased production of a specif...

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Bibliografiske detaljer
Main Authors: Raina, Kanak, Crews, Craig M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856979/
https://ncbi.nlm.nih.gov/pubmed/20147751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R109.078105
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