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Induced protein degradation: an emerging drug discovery paradigm
Small-molecule drug discovery has traditionally focused on occupancy of a binding site that directly affects protein function, which typically precludes targeting proteins that lack such amenable sites. Furthermore, high systemic drug exposures may be needed to maintain sufficient target inhibition...
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| Publicado no: | Nat Rev Drug Discov |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5684876/ https://ncbi.nlm.nih.gov/pubmed/27885283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd.2016.211 |
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