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Targeted Protein Degradation in Antibacterial Drug Discovery?
Drug induced degradation of a target protein is a novel concept in drug discovery. Traditionally drugs modulate activity, as opposed to abundance, of their targets. Degradation inducing ligands act catalytically. Thus, one advantage of target degradation over the classical on-target mechanism is tha...
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| Foilsithe in: | Prog Biophys Mol Biol |
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| Main Authors: | , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2019
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7145722/ https://ncbi.nlm.nih.gov/pubmed/31738980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbiomolbio.2019.11.005 |
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