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A critical evaluation of the approaches to targeted protein degradation for drug discovery
There is a great deal of excitement around the concept of targeting proteins for degradation as an alternative to conventional inhibitory small molecules and antibodies. Protein degradation can be undertaken by bifunctional molecules that bind the target for ubiquitin mediated degradation by complex...
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| Publicado no: | Drug Discov Today Technol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6559946/ https://ncbi.nlm.nih.gov/pubmed/31200859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2019.02.002 |
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