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A critical evaluation of the approaches to targeted protein degradation for drug discovery
There is a great deal of excitement around the concept of targeting proteins for degradation as an alternative to conventional inhibitory small molecules and antibodies. Protein degradation can be undertaken by bifunctional molecules that bind the target for ubiquitin mediated degradation by complex...
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| Pubblicato in: | Drug Discov Today Technol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6559946/ https://ncbi.nlm.nih.gov/pubmed/31200859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2019.02.002 |
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