Bivalent Ligands for Protein Degradation in Drug Discovery

Targeting the “undruggable” proteome remains one of the big challenges in drug discovery. Recent innovations in the field of targeted protein degradation and manipulation of the ubiquitin-proteasome system open up new therapeutic approaches for disorders that cannot be targeted with conventional inh...

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Bibliografiske detaljer
Udgivet i:Comput Struct Biotechnol J
Main Authors: Scheepstra, Marcel, Hekking, Koen F.W., van Hijfte, Luc, Folmer, Rutger H.A.
Format: Artigo
Sprog:Inglês
Udgivet: Research Network of Computational and Structural Biotechnology 2019
Fag:
Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369262/
https://ncbi.nlm.nih.gov/pubmed/30788082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2019.01.006
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