Monitoring ligand-induced protein ordering in drug discovery

While the gene for p53 is mutated in many human cancers causing loss of function, many others maintain a wild-type gene but exhibit reduced p53 tumor suppressor activity through overexpression of the negative regulators, Mdm2 and/or MdmX. For the latter mechanism of loss of function, the activity of...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Grace, Christy R, Ban, David, Min, Jaeki, Mayasundari, Anand, Min, Lie, Finch, Kristin E, Griffiths, Lyra, Bharatham, Nagakumar, Bashford, Donald, Guy, R. Kiplin, Dyer, Michael A., Kriwacki, Richard W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826315/
https://ncbi.nlm.nih.gov/pubmed/26812210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.01.016
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