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Ligand binding mode prediction by docking: Mdm2/Mdmx inhibitors as a case study
The p53-binding domains of Mdm2 and Mdmx, two negative regulators of the tumor suppressor, p53, are validated targets for cancer therapeutics, but correct binding poses of some proven inhibitors, particularly the nutlins, have been difficult to obtain with standard docking procedures. Virtual screen...
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| Publicado no: | J Chem Inf Model |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4753531/ https://ncbi.nlm.nih.gov/pubmed/24358984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci4004656 |
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