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Ligand binding mode prediction by docking: Mdm2/Mdmx inhibitors as a case study

The p53-binding domains of Mdm2 and Mdmx, two negative regulators of the tumor suppressor, p53, are validated targets for cancer therapeutics, but correct binding poses of some proven inhibitors, particularly the nutlins, have been difficult to obtain with standard docking procedures. Virtual screen...

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Bibliographic Details
Published in:J Chem Inf Model
Main Authors: Bharatham, Nagakumar, Bharatham, Kavitha, Shelat, Anang A., Bashford, Donald
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753531/
https://ncbi.nlm.nih.gov/pubmed/24358984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci4004656
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