Identification and Characterization of the First Small Molecule Inhibitor of MDMX

The p53 pathway is disrupted in virtually every human tumor. In ∼50% of human cancers, the p53 gene is mutated, and in the remaining cancers, the pathway is dysregulated by genetic lesions in other genes that modulate the p53 pathway. One common mechanism for inactivation of the p53 pathway in tumor...

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Main Authors: Reed, Damon, Shen, Ying, Shelat, Anang A., Arnold, Leggy A., Ferreira, Antonio M., Zhu, Fangyi, Mills, Nicholas, Smithson, David C., Regni, Catherine A., Bashford, Donald, Cicero, Samantha A., Schulman, Brenda A., Jochemsen, Aart G., Guy, R. Kiplin, Dyer, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856285/
https://ncbi.nlm.nih.gov/pubmed/20080970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.056747
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