Functions of MDMX in the Modulation of the p53-Response

по Lenos, Kristiaan, Jochemsen, Aart G.
Опубликовано 2011

MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond

по Marine, Jean-Christophe, Jochemsen, Aart G.
Опубликовано в: Cold Spring Harb Perspect Med (2016)

Activation of cAMP Signaling Interferes with Stress-Induced p53 Accumulation in ALL-Derived Cells by Promoting the Interaction between p53 and HDM2

по Naderi, Elin Hallan, Jochemsen, Aart G, Blomhoff, Heidi Kiil, Naderi, Soheil
Опубликовано 2011

Distinct Regulation of p53 and p73 Activity by Adenovirus E1A, E1B, and E4orf6 Proteins

по Steegenga, Wilma T., Shvarts, Avi, Riteco, Nicole, Bos, Johannes L., Jochemsen, Aart G.
Опубликовано 1999

Mutational Analysis of Fibrillarin and Its Mobility in Living Human Cells

по Snaar, Sabine, Wiesmeijer, Karien, Jochemsen, Aart G., Tanke, Hans J., Dirks, Roeland W.
Опубликовано 2000

Increased radio-resistance and accelerated B-cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA damage-activated kinases

по Wang, Yunyuan V., Leblanc, Mathias, Wade, Mark, Jochemsen, Aart G., Wahl, Geoffrey M.
Опубликовано 2009

HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target

по Souri, Zahra, Wierenga, Annemijn P.A., Mulder, Arend, Jochemsen, Aart G., Jager, Martine J.
Опубликовано в: Cancers (Basel) (2019)

Critical Role for a Central Part of Mdm2 in the Ubiquitylation of p53

по Meulmeester, Erik, Frenk, Ruth, Stad, Robert, de Graaf, Petra, Marine, Jean-Christophe, Vousden, Karen H., Jochemsen, Aart G.
Опубликовано 2003

Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro

по Schrage, Yvonne M, Lam, Suzanne, Jochemsen, Aart G, Cleton-Jansen, Anne-Marie, Taminiau, Antonie HM, Hogendoorn, Pancras CW, Bovée, Judith VMG
Опубликовано в: J Cell Mol Med (2009)

Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage

по Pereg, Yaron, Lam, Suzanne, Teunisse, Amina, Biton, Sharon, Meulmeester, Erik, Mittelman, Leonid, Buscemi, Giacomo, Okamoto, Koji, Taya, Yoichi, Shiloh, Yosef, Jochemsen, Aart G.
Опубликовано 2006

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

по Stad, Robert, Little, Natalie A., Xirodimas, Dimitris P., Frenk, Ruth, van der Eb, Alex J., Lane, David P., Saville, Mark K., Jochemsen, Aart G.
Опубликовано 2001

High levels of Hdmx promote cell growth in a subset of uveal melanomas

по de Lange, Job, Teunisse, Amina FAS, Vries, Matty Verlaan-de, Lodder, Kirsten, Lam, Suzanne, Luyten, Gregorius PM, Bernal, Federico, Jager, Martine J, Jochemsen, Aart G
Опубликовано 2012

Embryonic Zebrafish: Different Phenotypes after Injection of Human Uveal Melanoma Cells

по van der Ent, Wietske, Burrello, Claudia, de Lange, Mark J., van der Velden, Pieter A., Jochemsen, Aart G., Jager, Martine J., Snaar-Jagalska, B. Ewa
Опубликовано в: Ocul Oncol Pathol (2015)

Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis

по van IJzendoorn, David G. P., Forghany, Zary, Liebelt, Frauke, Vertegaal, Alfred C., Jochemsen, Aart G., Bovée, Judith V. M. G., Szuhai, Karoly, Baker, David A.
Опубликовано в: J Biol Chem (2017)

Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts

по Lenos, Kristiaan, de Lange, Job, Teunisse, Amina FAS, Lodder, Kirsten, Verlaan-de Vries, Matty, Wiercinska, Eliza, van der Burg, Marja JM, Szuhai, Karoly, Jochemsen, Aart G
Опубликовано 2011

Fluorescent CXCR4 targeting peptide as alternative for antibody staining in Ewing sarcoma

по Sand, Laurens G. L., Buckle, Tessa, van Leeuwen, Fijs W. B., Corver, Willem E., Kruisselbrink, Alwine B., Jochemsen, Aart G., Hogendoorn, Pancras C. W., Szuhai, Károly
Опубликовано в: BMC Cancer (2017)

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

по Pereg, Yaron, Shkedy, Dganit, de Graaf, Petra, Meulmeester, Erik, Edelson-Averbukh, Marina, Salek, Mogjiborahman, Biton, Sharon, Teunisse, Amina F. A. S., Lehmann, Wolf D., Jochemsen, Aart G., Shiloh, Yosef
Опубликовано 2005

Mdm4 supports DNA replication in a p53-independent fashion

по Wohlberedt, Kai, Klusmann, Ina, Derevyanko, Polina K., Henningsen, Kester, Choo, Josephine Ann Mun Yee, Manzini, Valentina, Magerhans, Anna, Giansanti, Celeste, Eischen, Christine M., Jochemsen, Aart G., Dobbelstein, Matthias
Опубликовано в: Oncogene (2020)

Analysis of CRISPR‐Cas9 screens identifies genetic dependencies in melanoma

по Christodoulou, Eirini, Rashid, Mamunur, Pacini, Clare, Droop, Alastair, Robertson, Holly, van Groningen, Tim, Teunisse, Amina F. A. S., Iorio, Francesco, Jochemsen, Aart G., Adams, David J., van Doorn, Remco
Опубликовано в: Pigment Cell Melanoma Res (2020)

DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

по Okamoto, Koji, Kashima, Kenji, Pereg, Yaron, Ishida, Michiko, Yamazaki, Satomi, Nota, Ayumi, Teunisse, Amina, Migliorini, Domenico, Kitabayashi, Issay, Marine, Jean-Christophe, Prives, Carol, Shiloh, Yosef, Jochemsen, Aart G., Taya, Yoichi
Опубликовано 2005