Activation of cAMP Signaling Interferes with Stress-Induced p53 Accumulation in ALL-Derived Cells by Promoting the Interaction between p53 and HDM2

The tumor suppressor p53 provides an important barrier to the initiation and maintenance of cancers. As a consequence, p53 function must be inactivated for a tumor to develop. This is achieved by mutation in approximately 50% of cases and probably by functional inactivation in the remaining cases. W...

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Main Authors: Naderi, Elin Hallan, Jochemsen, Aart G, Blomhoff, Heidi Kiil, Naderi, Soheil
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press Inc. 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132851/
https://ncbi.nlm.nih.gov/pubmed/21750659
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