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Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro

Chondrosarcomas are highly resistant to conventional radiation and chemotherapy, and surgical removal is the only option for curative treatment. Consequently, there is nothing to offer patients with inoperable tumours and metastatic disease. The aim of this study is to investigate genes involved in...

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Bibliografische gegevens
Gepubliceerd in:J Cell Mol Med
Hoofdauteurs: Schrage, Yvonne M, Lam, Suzanne, Jochemsen, Aart G, Cleton-Jansen, Anne-Marie, Taminiau, Antonie HM, Hogendoorn, Pancras CW, Bovée, Judith VMG
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Ltd 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498940/
https://ncbi.nlm.nih.gov/pubmed/18624751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00406.x
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