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Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo

BACKGROUND: Chondrosarcomas are malignant cartilage-forming tumors which are highly resistant to conventional chemotherapy and radiotherapy. Estrogen signaling is known to play an important role in proliferation and differentiation of chondrocytes and in growth plate regulation at puberty. Our exper...

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Библиографические подробности
Главные авторы: Meijer, Danielle, Gelderblom, Hans, Karperien, Marcel, Cleton-Jansen, Anne-Marie, Hogendoorn, Pancras CW, Bovée, Judith VMG
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372281/
https://ncbi.nlm.nih.gov/pubmed/22613849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3329-1-5
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