Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo

BACKGROUND: Chondrosarcomas are malignant cartilage-forming tumors which are highly resistant to conventional chemotherapy and radiotherapy. Estrogen signaling is known to play an important role in proliferation and differentiation of chondrocytes and in growth plate regulation at puberty. Our exper...

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Hlavní autoři: Meijer, Danielle, Gelderblom, Hans, Karperien, Marcel, Cleton-Jansen, Anne-Marie, Hogendoorn, Pancras CW, Bovée, Judith VMG
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372281/
https://ncbi.nlm.nih.gov/pubmed/22613849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3329-1-5
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