Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

In cycling cells, the retinoblastoma protein (pRb) is un- and/or hypo-phosphorylated in early G(1) and becomes hyper-phosphorylated in late G(1). The role of hypo-phosphorylation and identity of the relevant kinase(s) remains unknown. We show here that hypo-phosphorylated pRb associates with E2F in...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ezhevsky, Sergei A., Nagahara, Hikaru, Vocero-Akbani, Adita M., Gius, David R., Wei, Michael C., Dowdy, Steven F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23451/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9380698/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.20.10699
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