Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

Alterations of various components of the cell cycle regulatory machinery that controls the progression of cells from a quiescent to a growing state contribute to the development of many human cancers. Such alterations include the deregulated expression of G1 cyclins, the loss of function of activiti...

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Hlavní autoři: Khleif, S N, DeGregori, J, Yee, C L, Otterson, G A, Kaye, F J, Nevins, J R, Howley, P M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC39540/
https://ncbi.nlm.nih.gov/pubmed/8633069
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