Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

Alterations of various components of the cell cycle regulatory machinery that controls the progression of cells from a quiescent to a growing state contribute to the development of many human cancers. Such alterations include the deregulated expression of G1 cyclins, the loss of function of activiti...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Khleif, S N, DeGregori, J, Yee, C L, Otterson, G A, Kaye, F J, Nevins, J R, Howley, P M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39540/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8633069/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.9.4350
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