Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

In cycling cells, the retinoblastoma protein (pRb) is un- and/or hypo-phosphorylated in early G(1) and becomes hyper-phosphorylated in late G(1). The role of hypo-phosphorylation and identity of the relevant kinase(s) remains unknown. We show here that hypo-phosphorylated pRb associates with E2F in...

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Bibliographic Details
Main Authors: Ezhevsky, Sergei A., Nagahara, Hikaru, Vocero-Akbani, Adita M., Gius, David R., Wei, Michael C., Dowdy, Steven F.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC23451/
https://ncbi.nlm.nih.gov/pubmed/9380698
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