Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN‐amplified retinoblastoma

A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification. This manuscript investigated alternate pathways of inactivating pRb, the encoded protein in these tumors. We analyzed the m...

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Detaylı Bibliyografya
Yayımlandı:Cancer Med
Asıl Yazarlar: Ewens, Kathryn G., Bhatti, Tricia R., Moran, Kimberly A., Richards‐Yutz, Jennifer, Shields, Carol L., Eagle, Ralph C., Ganguly, Arupa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Cancer Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345671/
https://ncbi.nlm.nih.gov/pubmed/28211617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1010
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