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Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN‐amplified retinoblastoma

A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification. This manuscript investigated alternate pathways of inactivating pRb, the encoded protein in these tumors. We analyzed the m...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Ewens, Kathryn G., Bhatti, Tricia R., Moran, Kimberly A., Richards‐Yutz, Jennifer, Shields, Carol L., Eagle, Ralph C., Ganguly, Arupa
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345671/
https://ncbi.nlm.nih.gov/pubmed/28211617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1010
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