Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN‐amplified retinoblastoma

A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification. This manuscript investigated alternate pathways of inactivating pRb, the encoded protein in these tumors. We analyzed the m...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Med
Egile Nagusiak: Ewens, Kathryn G., Bhatti, Tricia R., Moran, Kimberly A., Richards‐Yutz, Jennifer, Shields, Carol L., Eagle, Ralph C., Ganguly, Arupa
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2017
Gaiak:
Cancer Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345671/
https://ncbi.nlm.nih.gov/pubmed/28211617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1010
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