p107 is a suppressor of retinoblastoma development in pRb-deficient mice
Hemizygosity for the retinoblastoma gene RB in man strongly predisposes to retinoblastoma. In the mouse, however, Rb hemizygosity leaves the retina normal, whereas in Rb(−/−) chimeras pRb-deficient retinoblasts undergo apoptosis. To test whether concomitant inactivation of the Rb-related gene p107 i...
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| Publicado no: | Genes Dev |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316874/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9620848/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.11.1599 |
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