p107 is a suppressor of retinoblastoma development in pRb-deficient mice

Hemizygosity for the retinoblastoma gene RB in man strongly predisposes to retinoblastoma. In the mouse, however, Rb hemizygosity leaves the retina normal, whereas in Rb(−/−) chimeras pRb-deficient retinoblasts undergo apoptosis. To test whether concomitant inactivation of the Rb-related gene p107 i...

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Detalles Bibliográficos
Publicado en:Genes Dev
Main Authors: Robanus-Maandag, Els, Dekker, Marleen, van der Valk, Martin, Carrozza, Maria-Luisa, Jeanny, Jean-Claude, Dannenberg, Jan-Hermen, Berns, Anton, te Riele, Hein
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1998
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316874/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9620848/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.11.1599
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