p107 is a suppressor of retinoblastoma development in pRb-deficient mice

Hemizygosity for the retinoblastoma gene RB in man strongly predisposes to retinoblastoma. In the mouse, however, Rb hemizygosity leaves the retina normal, whereas in Rb(−/−) chimeras pRb-deficient retinoblasts undergo apoptosis. To test whether concomitant inactivation of the Rb-related gene p107 i...

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Bibliografski detalji
Glavni autori: Robanus-Maandag, Els, Dekker, Marleen, van der Valk, Martin, Carrozza, Maria-Luisa, Jeanny, Jean-Claude, Dannenberg, Jan-Hermen, Berns, Anton, te Riele, Hein
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 1998
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC316874/
https://ncbi.nlm.nih.gov/pubmed/9620848
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