Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas.

Biopsies from 61 sporadic metastatic malignant melanomas and five melanoma cell lines were examined for homozygous deletions and mutations in the CDKN2 gene (p16). As the p16 protein is involved in a cell cycle regulatory pathway consisting of at least pRb, cdk4 and cyclin D1, the tumours were also...

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Main Authors: Maelandsmo, G. M., Flørenes, V. A., Hovig, E., Oyjord, T., Engebraaten, O., Holm, R., Børresen, A. L., Fodstad, O.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 1996
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075830/
https://ncbi.nlm.nih.gov/pubmed/8611425
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