The role of p16-cyclin D/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma

We analysed p16 gene alteration and p16, cyclin-dependent kinase 4 (CDK4), CDK6, cyclin D1, cyclin D2, cyclin D3 and retinoblastoma protein (pRb) expression in ten normal endometriums (PE), 18 endometrial hyperplasias (EH) and 35 endometrial cancers (EC). Two of ten PE (20%), nine of 18 EH (50.0%) a...

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Bibliographic Details
Main Authors: Tsuda, H, Yamamoto, K, Inoue, T, Uchiyama, I, Umesaki, N
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2000
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363310/
https://ncbi.nlm.nih.gov/pubmed/10682682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.1999.0980
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