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Human Colorectal Cancers with an Intact p16/Cyclin D1/pRb Pathway Have Up-Regulated p16 Expression and Decreased Proliferation in Small Invasive Tumor Clusters

A systematic spatial heterogeneity with high proliferative activity at the luminal border and low activity at the invasive margin is an unexpected behavior that has been observed in colorectal cancer (CRC). To clarify this phenomenon and possible underlying regulatory mechanisms, we have by immunohi...

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Bibliographic Details
Main Authors: Palmqvist, Richard, Rutegård, Jörgen N., Bozoky, Bela, Landberg, Göran, Stenling, Roger
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277300/
https://ncbi.nlm.nih.gov/pubmed/11106567
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