Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage

The p53 tumor suppressor plays a major role in maintaining genomic stability. Its activation and stabilization in response to double strand breaks (DSBs) in DNA are regulated primarily by the ATM protein kinase. ATM mediates several posttranslational modifications on p53 itself, as well as phosphory...

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Main Authors: Pereg, Yaron, Lam, Suzanne, Teunisse, Amina, Biton, Sharon, Meulmeester, Erik, Mittelman, Leonid, Buscemi, Giacomo, Okamoto, Koji, Taya, Yoichi, Shiloh, Yosef, Jochemsen, Aart G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592859/
https://ncbi.nlm.nih.gov/pubmed/16943424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00562-06
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