HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of the HDMX Gene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity

The p53 regulatory network is critically involved in preventing the initiation of cancer. In unstressed cells, p53 is maintained at low levels and is largely inactive, mainly through the action of its two essential negative regulators, HDM2 and HDMX. p53 abundance and activity are up-regulated in re...

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Detalhes bibliográficos
Main Authors: Phillips, Anna, Teunisse, Amina, Lam, Suzanne, Lodder, Kirsten, Darley, Matthew, Emaduddin, Muhammad, Wolf, Anja, Richter, Julia, de Lange, Job, Verlaan-de Vries, Matty, Lenos, Kristiaan, Böhnke, Anja, Bartel, Frank, Blaydes, Jeremy P., Jochemsen, Aart G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937942/
https://ncbi.nlm.nih.gov/pubmed/20659896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129726
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