Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX

Inactivation of the p53 tumour suppressor, either by mutation or by overexpression of its inhibitors Hdm2 and HdmX is the most frequent event in cancer. Reactivation of p53 by targeting Hdm2 and HdmX is therefore a promising strategy for therapy. However, Hdm2 inhibitors do not prevent inhibition of...

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Detalhes bibliográficos
Main Authors: Spinnler, C, Hedström, E, Li, H, de Lange, J, Nikulenkov, F, Teunisse, A F A S, Verlaan-de Vries, M, Grinkevich, V, Jochemsen, A G, Selivanova, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190111/
https://ncbi.nlm.nih.gov/pubmed/21546907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.45
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