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Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
The p53 protein maintains genomic integrity through its ability to induce cell cycle arrest or apoptosis in response to various forms of stress. Substantial regulation of p53 activity occurs at the level of protein stability, largely determined by the activity of the Mdm2 protein. Mdm2 targets both...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1084126/ https://ncbi.nlm.nih.gov/pubmed/11606419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve227 |
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