Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

The p53 protein maintains genomic integrity through its ability to induce cell cycle arrest or apoptosis in response to various forms of stress. Substantial regulation of p53 activity occurs at the level of protein stability, largely determined by the activity of the Mdm2 protein. Mdm2 targets both...

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Bibliografiske detaljer
Main Authors: Stad, Robert, Little, Natalie A., Xirodimas, Dimitris P., Frenk, Ruth, van der Eb, Alex J., Lane, David P., Saville, Mark K., Jochemsen, Aart G.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2001
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084126/
https://ncbi.nlm.nih.gov/pubmed/11606419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve227
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