Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

The p53 protein maintains genomic integrity through its ability to induce cell cycle arrest or apoptosis in response to various forms of stress. Substantial regulation of p53 activity occurs at the level of protein stability, largely determined by the activity of the Mdm2 protein. Mdm2 targets both...

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Bibliografski detalji
Glavni autori: Stad, Robert, Little, Natalie A., Xirodimas, Dimitris P., Frenk, Ruth, van der Eb, Alex J., Lane, David P., Saville, Mark K., Jochemsen, Aart G.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2001
Teme:
Scientific Reports
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084126/
https://ncbi.nlm.nih.gov/pubmed/11606419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve227
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