Identification and Characterization of the First Small Molecule Inhibitor of MDMX

The p53 pathway is disrupted in virtually every human tumor. In ∼50% of human cancers, the p53 gene is mutated, and in the remaining cancers, the pathway is dysregulated by genetic lesions in other genes that modulate the p53 pathway. One common mechanism for inactivation of the p53 pathway in tumor...

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Main Authors: Reed, Damon, Shen, Ying, Shelat, Anang A., Arnold, Leggy A., Ferreira, Antonio M., Zhu, Fangyi, Mills, Nicholas, Smithson, David C., Regni, Catherine A., Bashford, Donald, Cicero, Samantha A., Schulman, Brenda A., Jochemsen, Aart G., Guy, R. Kiplin, Dyer, Michael A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
Cell Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856285/
https://ncbi.nlm.nih.gov/pubmed/20080970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.056747
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