Φορτώνει......
Monitoring ligand-induced protein ordering in drug discovery
While the gene for p53 is mutated in many human cancers causing loss of function, many others maintain a wild-type gene but exhibit reduced p53 tumor suppressor activity through overexpression of the negative regulators, Mdm2 and/or MdmX. For the latter mechanism of loss of function, the activity of...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Mol Biol |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4826315/ https://ncbi.nlm.nih.gov/pubmed/26812210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.01.016 |
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