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Targeted Protein Degradation in Antibacterial Drug Discovery?
Drug induced degradation of a target protein is a novel concept in drug discovery. Traditionally drugs modulate activity, as opposed to abundance, of their targets. Degradation inducing ligands act catalytically. Thus, one advantage of target degradation over the classical on-target mechanism is tha...
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| Pubblicato in: | Prog Biophys Mol Biol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7145722/ https://ncbi.nlm.nih.gov/pubmed/31738980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbiomolbio.2019.11.005 |
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