Cdc1p Is an Endoplasmic Reticulum-Localized Putative Lipid Phosphatase That Affects Golgi Inheritance and Actin Polarization by Activating Ca(2+) Signaling

Por Losev, Eugene, Papanikou, Effrosyni, Rossanese, Olivia W., Glick, Benjamin S.
Publicado em 2008

Golgi Structure Correlates with Transitional Endoplasmic Reticulum Organization in Pichia pastoris and Saccharomyces cerevisiae

Por Rossanese, Olivia W., Soderholm, Jon, Bevis, Brooke J., Sears, Irina B., O'Connor, James, Williamson, Edward K., Glick, Benjamin S.
Publicado em 1999

A Role for Actin, Cdc1p, and Myo2p in the Inheritance of Late Golgi Elements in Saccharomyces cerevisiae

Por Rossanese, Olivia W., Reinke, Catherine A., Bevis, Brooke J., Hammond, Adam T., Sears, Irina B., O'Connor, James, Glick, Benjamin S.
Publicado em 2001

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation

Por Sun, Qi, Burke, Jason P., Phan, Jason, Burns, Michael C., Olejniczak, Edward T., Waterson, Alex G., Lee, Taekyu, Rossanese, Olivia W., Fesik, Stephen W.
Publicado em 2012

A high-throughput fluorescence polarization anisotropy assay for the 70N domain of Replication Protein A

Por Souza-Fagundes, Elaine M., Frank, Andreas O., Feldkamp, Michael D., Dorset, Daniel C., Chazin, Walter J., Rossanese, Olivia W., Olejniczak, Edward T., Fesik, Stephen W.
Publicado em 2011

A Yeast t-SNARE Involved in Endocytosis

Por Séron, Karin, Tieaho, Ville, Prescianotto-Baschong, Cristina, Aust, Thomas, Blondel, Marie-Odile, Guillaud, Philippe, Devilliers, Ginette, Rossanese, Olivia W., Glick, Benjamin S., Riezman, Howard, Keränen, Sirkka, Haguenauer-Tsapis, Rosine
Publicado em 1998

Discovery of Protein–Protein Interaction Inhibitors of Replication Protein A

Por Patrone, James D., Kennedy, J. Phillip, Frank, Andreas O., Feldkamp, Michael D., Vangamudi, Bhavatarini, Pelz, Nicholas F., Rossanese, Olivia W., Waterson, Alex G., Chazin, Walter J., Fesik, Stephen W.
Publicado em 2013

Golgi enlargement in Arf-depleted yeast cells is due to altered dynamics of cisternal maturation

Por Bhave, Madhura, Papanikou, Effrosyni, Iyer, Prasanna, Pandya, Koushal, Jain, Bhawik Kumar, Ganguly, Abira, Sharma, Chandrakala, Pawar, Ketakee, Austin, Jotham, Day, Kasey J., Rossanese, Olivia W., Glick, Benjamin S., Bhattacharyya, Dibyendu
Publicado em 2014

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Por Burns, Michael C., Sun, Qi, Daniels, R. Nathan, Camper, DeMarco, Kennedy, J. Phillip, Phan, Jason, Olejniczak, Edward T., Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.
Publicado em 2014

Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A

Por Frank, Andreas O., Vangamudi, Bhavatarini, Feldkamp, Michael D., Souza-Fagundes, Elaine M., Luzwick, Jessica W., Cortez, David, Olejniczak, Edward T., Waterson, Alex G., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.
Publicado em 2014

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling

Por Burns, Michael C., Howes, Jennifer E., Sun, Qi, Little, Andrew J., Camper, DeMarco V., Abbott, Jason R., Phan, Jason, Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.
Publicado no Anal Biochem (2018)

Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions Using a Fragment Linking Approach

Por Frank, Andreas O., Feldkamp, Michael D., Kennedy, J. Phillip, Waterson, Alex G., Pelz, Nicholas F., Patrone, James D., Vangamudi, Bhavatarini, Camper, DeMarco V., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.
Publicado em 2013

Diphenylpyrazoles as Replication Protein A Inhibitors

Por Waterson, Alex G., Kennedy, J. Phillip, Patrone, James D., Pelz, Nicholas F., Feldkamp, Michael D., Frank, Andreas O., Vangamudi, Bhavatarini, Souza-Fagundes, Elaine M., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.
Publicado no ACS Med Chem Lett (2014)

Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS

Por Abbott, Jason R., Patel, Pratiq A., Howes, Jennifer E., Akan, Denis T., Kennedy, J. Phillip, Burns, Michael C., Browning, Carrie F., Sun, Qi, Rossanese, Olivia W., Phan, Jason, Waterson, Alex G., Fesik, Stephen W.
Publicado no ACS Med Chem Lett (2018)

Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design

Por Burke, Jason P., Bian, Zhiguo, Shaw, Subrata, Zhao, Bin, Goodwin, Craig M., Belmar, Johannes, Browning, Carrie F., Vigil, Dominico, Friberg, Anders, Camper, DeMarco V., Rossanese, Olivia W., Lee, Taekyu, Olejniczak, Edward T., Fesik, Stephen W.
Publicado no J Med Chem (2015)

DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

Por Kanu, Nnennaya, Cerone, Maria Antonietta, Goh, Gerald, Zalmas, Lykourgos-Panagiotis, Bartkova, Jirina, Dietzen, Michelle, McGranahan, Nicholas, Rogers, Rebecca, Law, Emily K., Gromova, Irina, Kschischo, Maik, Walton, Michael I., Rossanese, Olivia W., Bartek, Jiri, Harris, Reuben S., Venkatesan, Subramanian, Swanton, Charles
Publicado no Genome Biol (2016)

Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods

Por Pelz, Nicholas F., Bian, Zhiguo, Zhao, Bin, Shaw, Subrata, Tarr, James C., Belmar, Johannes, Gregg, Claire, Camper, DeMarco V., Goodwin, Craig M., Arnold, Allison L., Sensintaffar, John L., Friberg, Anders, Rossanese, Olivia W., Lee, Taekyu, Olejniczak, Edward T., Fesik, Stephen W.
Publicado no J Med Chem (2016)

Identification and Optimization of Anthranilic Acid-Based Inhibitors of Replication Protein A

Por Patrone, James D., Pelz, Nicholas F., Bates, Brittney S., Souza-Fagundes, Elaine M., Vangamudi, Bhavatarini, Camper, Demarco V., Kuznetsov, Alexey G., Browning, Carrie F., Feldkamp, Michael D., Frank, Andreas O., Gilston, Benjamin A., Olejniczak, Edward T., Rossanese, Olivia W., Waterson, Alex G., Chazin, Walter J., Fesik, Stephen W.
Publicado no ChemMedChem (2016)

Discovery of Potent 2-Aryl-6,7-Dihydro-5H-Pyrrolo[1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Por Wang, Feng, Jeon, Kyu Ok, Salovich, James M., Macdonald, Jonathan D., Alvarado, Joseph, Gogliotti, Rocco D., Phan, Jason, Olejniczak, Edward T., Sun, Qi, Wang, Shidong, Camper, DeMarco, Yuh, Joannes P., Shaw, J. Grace, Sai, Jiqing, Rossanese, Olivia W., Tansey, William P., Stauffer, Shaun R., Fesik, Stephen W.
Publicado no J Med Chem (2018)

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

Por Rheault, Tara R., Stellwagen, John C., Adjabeng, George M., Hornberger, Keith R., Petrov, Kimberly G., Waterson, Alex G., Dickerson, Scott H., Mook, Robert A., Laquerre, Sylvie G., King, Alastair J., Rossanese, Olivia W., Arnone, Marc R., Smitheman, Kimberly N., Kane-Carson, Laurie S., Han, Chao, Moorthy, Ganesh S., Moss, Katherine G., Uehling, David E.
Publicado em 2013