Identification and Optimization of Anthranilic Acid-Based Inhibitors of Replication Protein A

Replication Protein A (RPA) is an essential single-stranded DNA (ssDNA) binding protein that initiates the DNA damage response pathway through protein-protein interactions (PPIs) mediated by its 70N domain. The identification and use of chemical probes that can specifically disrupt these interaction...

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Publicado no:ChemMedChem
Main Authors: Patrone, James D., Pelz, Nicholas F., Bates, Brittney S., Souza-Fagundes, Elaine M., Vangamudi, Bhavatarini, Camper, Demarco V., Kuznetsov, Alexey G., Browning, Carrie F., Feldkamp, Michael D., Frank, Andreas O., Gilston, Benjamin A., Olejniczak, Edward T., Rossanese, Olivia W., Waterson, Alex G., Chazin, Walter J., Fesik, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838552/
https://ncbi.nlm.nih.gov/pubmed/26748787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500479
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