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Surface reengineering of RPA70N enables co-crystallization with an inhibitor of the RPA interaction motif of ATRIP
Replication Protein A (RPA) is the primary single stranded DNA (ssDNA) binding protein in eukaryotes. The N-terminal domain of the RPA70 subunit (RPA70N) interacts via a basic cleft with a wide range of DNA processing proteins, including several that regulate DNA damage response and repair. Small mo...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3804075/ https://ncbi.nlm.nih.gov/pubmed/23962067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400542z |
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