Discovery of Protein–Protein Interaction Inhibitors of Replication Protein A

[Image: see text] Replication protein A (RPA) is a ssDNA binding protein that is essential for DNA replication and repair. The initiation of the DNA damage response by RPA is mediated by protein–protein interactions involving the N-terminal domain of the 70 kDa subunit with partner proteins. Inhibit...

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Main Authors: Patrone, James D., Kennedy, J. Phillip, Frank, Andreas O., Feldkamp, Michael D., Vangamudi, Bhavatarini, Pelz, Nicholas F., Rossanese, Olivia W., Waterson, Alex G., Chazin, Walter J., Fesik, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728914/
https://ncbi.nlm.nih.gov/pubmed/23914285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400032y
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